inSPIN - from structure to biological intervention

The mission of inSPIN is to perform structural characterization to generate knowledge that can be used systematically to design ways for biological intervention. We will generate and exploit results from structural and functional analysis to rationally design synthetic antimicrobial peptides, small molecule inhibitors for fibril formation, new contrast agents for early-stage detection of amyloid diseases, and a molecular basis for understanding extracellular matrix degradation, to name some specific targets.

Positions for students and postdocs

While a good understanding of soluble proteins is available, our focus is the more challenging group of "insoluble" proteins for which only little structural information is available.