Publications - Theses

Peer reviewed publications

 
In press
262.  R. Taaning and T. Skrydstrup. Encyclopedia on Reagents for Org (In press).
(S)-4-Benzyl-2-oxazolidinone.
261.  S. G. Hansen and T. Skrydstrup. Current Topics in Chemistry (In press).
Current Topics in Chemistry (2006). Modification of Carbohydrates, Amino Acids and Peptides Via Radical Reactions
260.  S.V. Petersen, I.B. Thøgersen, Z. Valnickova, M.S. Nielsen, J.S. Petersen, E.T. Poulsen, C. Jacobsen, T. D. Oury, S.K. Moestrup, J.D. Crapo, N.C. Nielsen, T. Kristensen, and J.J. Enghild. Free Radical Biology and Medicine (In press).
The Concentration of Extracellular Superoxide Dismutase (EC-SOD) in Plasma is Maintained by LRP-Mediated Endocytosis
 
2010
259.  S. Jespersen, C. R. Bjarkam,, J. R. Nyengaard, M. M. Chakravarty, B. Hansen, T. Vosegaard, L. Østergaard, D. Yablonskiy, and N. C. Nielsen and P. Vestergaard-Poulsen. NeuroImage 49, 205 (2010).
Neurite density from magnetic resonance diffusion measurements at ultrahigh field: comparison with light microscopy and electron microscopy
258.  M. Jensen, M. Bjerring, N.C. Nielsen, W. Nerdal. J. Biol. Inorg. Chem. 15, 213 (2010).
Cisplatin interaction with phosphatidylserine bilayer studied by solid-state NMR spectroscopy
257.  B. S. Vad, L. A. Thomsen, K. Bertelsen, M. Franzmann, J. M. Pedersen, S. B. Nielsen, T. Vosegaard, Z. Valnickova, T. Skrydstrup, J. J. Enghild, R. Wimmer, N. C. Nielsen, and D. E. Otzen. Biochim. Biophys. Acta 1804, 806 (2010).
Divorcing Folding from Function: How Acylation Affects the Membrane-perturbing Properties of an Anti-microbial Peptide
256.  M.Ø. Pedersen, J. Linnanto, N.-U. Frigaard, N.C. Nielsen, and M. Miller. Photosynth. Res 104, 233 (2010).
A Model of the Protein-Pigment Baseplate Complex in Chlorosomes of Photosynthetic Green Bacteria
255.  M. Bayley, J. Overgaard, A. S. Høj, A. Malmendal, N. C. Nielsen, M. Holmstrup, and T. Wang. Phys. Biochem. Zool 83, 541 (2010).
Metabonomic Changes During Aestivation in the Common Earthworm Aporrectodea caliginosa
254.  J. F. Young, L. B. Larsen, A. Malmendal, N. C. Nielsen, I. K. Straadt, N. Oksbjerg, and H. C. Bertram. Journal of the International Society of Sports Nutrition 7:9, 1 (2010).
Creatine-induced activation of antioxidative defence in myotube cultures revealed by explorative NMR-based metabonomics and proteomics
253.  I.I. Maximov, J. Salomon, G. Turinici, and N. Nielsen. J. Chem. Phys. 132, 084107-1 (2010).
A smoothing monotonic convergent optimal control algorithm for NMR pulse sequence design
252.  B. Vad, K. Bertelsen, C.H. Johansen, J.M. Pedersen, T. Skrydstrup, N.C. Nielsen, and D.E. Otzen. Biophysical Journal 98, 576 (2010).
The Antimicrobial Peptide Pardaxin Displays a pH- and Lipid-Dependent Interaction with Lipid Bilayers
251.  T. Vosegaard, Z. Tosner, and N. C. Nielsen. in Encyclopedia of Magnetic Resonance, Ed. R. K. Harris and R. E. Wasylishen (2010).
Numerical Simulations in Solid-State NMR with SIMPSON
250.  N.C. Nielsen, C. Kehlet, S.J. Glaser, N. Khaneja. in Encyclopedia of Magnetic Resonance, Ed. R. K. Harris and R. E. Wasylishen (2010).
Optimal control methods in NMR
249.  A. Malmendal, J. Underhaug, D.E. Otzen, and N.C. Nielsen. PloS ONE 5, e10626 1 (2010).
Fast Mapping of Global Protein Folding States by Multivariate NMR: A GPS for Proteins
248.  A.B. Nielsen, L.A. Straasø, A.J. Nieuwkoop, C.M. Rienstra, M. Bjerring, N.C. Nielsen. J. Phys. Chem. Lett 1, 1952 (2010).
Broadband Heteronuclear Solid-State NMR Experiments by Exponentially Modulated Dipolar Recoupling without Decoupling
247.  M. Bjerring, A.B. Nielsen, Z. Tosner, N.C. Nielsen. Chem. Phys. Lett. 494, 326 (2010).
Broadband heteronuclear dipolar recoupling without 1H decoupling in solid-state NMR using simple cross-polarization methods
246.  D. Waagner, L.-H. Heckmann, A. Malmendal, N.C. Nielsen, M. Holmstrup, and M. Bayley. Comparative Biochemistry and Phy 157, 177 (2010).
Hsp70 expression and metabolite composition in response to short-term thermal changes in Folsomia candida
245.  L.A. Straasoe, N.C. Nielsen. J. Chem. Phys. 133, 064501-1 (2010).
Recoupling of Native Homonuclear Dipolar Couplings in Magic-Angle-Spinning Solid-State NMR by the Double-Oscillating Field Technique
244.  C. Laustsen, S. Ringgaard, M. Pedersen, and N.C. Nielsen. J. Magn. Reson. 206, 139 (2010).
Quadrupolar-coupling-specific binomial pulse sequences for in vivo 23Na NMR and MRI
243.  J. Dorosz, S. Kolusheva, Y. Gofman, D.E. Otzen, N. Ben-Tal, N.C. Nielsen, and R. Jelinek. J. Phys. Chem. B , (2010).
Membrane Interaction of Novicidin, a Novel Antimicrobial Peptide: Phophatidylglycerole Promotes Bilayer Insertion
 
2009
242.  J. T. Nielsen, M. Bjerring, M. D. Jeppesen, R. O. Pedersen, J. M. Pedersen, K. L. Hein, T. Vosegaard, T. Skrydstrup, D. E. Otzen, and N. C. Nielsen. Angew. Chem. Intl. Ed. 48, 2118 (2009).
Unique identification of supramolecular structures in amyloid fibrils by solid-state NMR spectroscopy
241.  Z. Tosner, T. Vosegaard, C. T. Kehlet, N. Khaneja, S. Glaser, and N. C. Nielsen. J. Magn. Reson. 197, 120 (2009).
Optimal Control in NMR Spectroscopy: Numerical implementation in SIMPSON
240.  C. U. Hjørringgaard, J. M. Pedersen, T. Vosegaard, N. C. Nielsen, and T. Skrydstrup. J. Org. Chem. 74, 1329 (2009).
An Automatic Solid Phase Synthesis of Peptaibols
239.  J. Dittmer, L. Thøgersen, J. Underhaug, K. Bertelsen, T. Vosegaard, J. M. Pedersen, B. Schiøtt, E. Tajkhorshid, T. Skrydstrup, and N. C. Nielsen. J. Phys. Chem. B 113, 6928 (2009).
Incorporation of Antimicrobial Peptides into Membranes: A Combined Liquid-State NMR and Molecular Dynamics Study of Alamethicin in DMPC/DHPC Bicelles
238.  T. Vosegaard and N. C. Nielsen. J. Magn. Reson. 199, 146 (2009).
Defining the sampling space in multidimensional NMR experiments: What should the maximum sampling time be?
237.  H. C. Bertram, N. B. Kristensen, M. Vestergaard, S. K. Jensen, J. Sehested, N. C. Nielsen, and A. Malmendal. Livestock Science 120, 127 (2009).
Metabolic Characterization of Rumen Epithelial Tissue from Dairy Calves Fed Different Starter Diets using 1H NMR Spectroscopy
236.  T. H. V. Huynh, M. L. Mantel, K. Mikkelsen, A. T. Lindhart, N. C. Nielsen, D. Otzen, and T. Skrydstrup. Org. Lett. 11, 999 (2009).
A versatile approach to a-amyloid fibril-binding compounds exploiting the Shirakawa/Hayashi protocol for trans-alkene synthesis
235.  J. Stec-Niemczyk, K. Pustelny, M. Kisielewska, M. Bista, K.T. Boulware, H.R. Stennicke, I.B. Thogersen, P.S. Daugherty, J.J. Enghild, K. Baczynski, G.M. Popowicz, A. Dubin, J. Potempa, and G. Dubin. Biophysical Journal 419, 555 (2009).
Structural and functional characterization of SplA, an exclusively specific protease of Staphylococcus aureus
234.  K. Runager, R. Garcia-Castellanos, Z. Valnickova, T. Kristensen, N. C. Nielsen, G. K. Klintworth, F. X. Gomis-Rüth, and J. J. Enghild. Acta Cryst. 65, 299 (2009).
Purification, crystallization, and preliminary X-ray diffraction of wild-type and mutant recombinant transforming growth factor beta induced protein (TGFBIp)
233.  L. Nesgaard, B. Vad, G. Christiansen, and D. E. Otzen. Biochim. Biophys. Acta 1794, 84 (2009).
Kinetic partitioning between aggregation and vesicle permeabilization by modified ADan
232.  D. E. Otzen, P. Sehgal, P. Westh, and J. Coll. Int. Sci. 329, 273 (2009).
a-lactalbumin is unfolded by all classes of detergents but with different mechanisms
231.  S. Dam, B. S. Laursen, J. H. Ornfelt, B. Jochimsen, H. H. Stærfeldt, C. Friis, K. Nielsen, N. Goffard, S. Besenbacher, L. Krusell, S. Sato, S. Tabata, I. B. Thøgersen, J. J. Enghild, and J. Stougaard.. Plamt Physiol 149, 1325 (2009).
The Proteome of Seed Development in the Model Legume Lotus japonicus
230.  E. Colón, A. Shytuhina, M. K. Cowman, P. A. Band K. W. Sanggaard, J. J. Enghild, and H. G. Wisniewski . J. Biol. Chem. 284, 2320 (2009).
Transfer of inter-alpha-inhibitor heavy chains to hyaluronan by surface-linked hyaluronan-TSG-6 complexes
229.  R. Halaban, M. Krauthammer, M. Pelizzola, E. Cheng, D. Kovacs, M. Sznol, S. Ariyan, D. Narayan, A. Bacchiocchi, A. Molinaro, Y. Kluger, M. Deng, N. Tran, W. Zhang, M. Picardo, and J. J. Enghild. PLoS ONE 4, e4563 (2009).
Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications
228.  J. H. Hansen, J. H., S. V. Petersen, K. K. Andersen, J. J. Enghild, T. Damhus, and D. E. Otzen. Biopolymers 91, 221 (2009).
Stable intermediates determine proteins’ primary unfolding sites in the presence of surfactants
227.  T. M. Gøgsig, A. T. Lindhardt, and T. Skrydstrup. J. Org. Chem. 74, 135 (2009).
1,2–-Migrations in Pd-Catalyzed Negishi Couplings with Josiphos Ligands
226.  K. Dooleweerdt, T. Ruhl, and T. Skrydstrup. Org. Lett. 11, 221 (2009).
Application of Ynamides in the Synthesis of 2-Amidoindoles
225.  H. C. Bertram, A. Malmendal, N. C. Nielsen, I. K. Straadt, T. Larsen, K. E. B. Knudsen, and H. N. Lærke. Mol. Nutrition Food Res 53, 1055 (2009).
NMR-based metabonomics reveals that betaine plasma betaine increases upon intake of high-fiber rye buns in hypercholesterolaemic pigs
224.  L. A. Straasø, M. Bjerring, N. Khaneja, and N. C. Nielsen. J. Chem. Phys. 130, 225103-1 (2009).
Multiple-oscillating-field techniques for accurate distance measurements by solid-state NMR
223.  A.B. Nielsen, M. Bjerring, J.T. Nielsen, N.C. Nielsen. J. Chem. Phys. 131, 025101-1 (2009).
Symmetry-based dipolar recoupling by optimum control: Band selective experiments for assignment of solid-state NMR spectra of proteins
222.  M. Goswami, P. K. Madhu, J. Dittmer, N. C. Nielsen, and S. Ganapathy. Chem. Phys. Lett. 478, 287 (2009).
Sensitivity Enhancement of 29Si Double-Quantum Dipolar Recoupling Spectroscopy by Carr-Purcell-Meiboom-Gill Acquisition Method
221.  T. Mittag, N. C. Nielsen, D. Otzen, and T. S. Skrydstrup. J. Org. Chem. 74, 7955 (2009).
An Expedient Synthesis of a Hydroxyethylene Isostre of the Fibrillating Peptide NFGAIL: Application of a SmI2-Promoted C-C forming Reaction in the Key Step
220.  K. Bertelsen, B. Paaske, L. Thøgersen, E. Tajkhorshid, B. Schiøtt, T. Skrydstrup, N. C. Nielsen, and T. Vosegaard. J. Am. Chem. Soc. 131, 18335 (2009).
Residue-Specific Information about the Dynamics of Antimicrobial Peptides from 1H-15N and 2H Solid-State NMR Spectroscopy
 
2008
219.  T. Vosegaard, K. Bertelsen, J. M. Pedersen, L. Thøgersen, B. Schiøtt, E. Tajkhorshid, T. Skrydstrup, and N. C. Nielsen. J. Am. Chem. Soc. 130, 5028 (2008).
Resolution Enhancement in Solid-State NMR of Oriented Membrane Proteins by Anisotropic Differential Linebroadening
218.  M. Bjerring, J.S. Nielsen, A. Siu, N.C. Nielsen, F.C. Krebs. Solar Energy Materials and Solar Cells 92, 772 (2008).
An explanation for the high stability of polycarboxythiophenes in photovoltaic devices - A by solid-state NMR dipolar recoupling study
217.  T. Vosegaard, M. Kamihira-Ishijima, A. Watts, and N. C. Nielsen. Biophys. J. 94, 241 (2008).
Helix conformations in 7TM membrane proteins determined using oriented-sample solid-state NMR with multiple residue specific 15N labeling
216.  N. Khaneja, N.C. Nielsen. J. Chem. Phys. 128, 015103-1 (2008).
Triple Oscillating Field Technique for Accurate Distance Measurements by Solid-State NMR
215.  T. Mittag, K. L. Christensen, K. B. Lindsay, N. C. Nielsen, and T. Skrydstrup. J. Org. Chem. 73, 1088 (2008).
Direct Entry to Peptidyl Ketones via SmI2-Mediated C-C Bond Formation with Readily Accessible N-Peptidyl Oxazoldinones
214.  K. E. Nielsen, J. Dittmer, A. Malmendal, and N. C. Nielsen. Energy & Fuels 22, 4070 (2008).
Quantitative analysis of constituents in heavy fuel oil by 1H Nuclear Magnetic Resonance (NMR) spectroscopy and multivariate data analysis
213.  S. Slotsbo, K. Maraldo, A. Malmendal, N. C. Nielsen, and M. Holmstrup. Cryobiology 57, 286 (2008).
Freeze-tolerance and accumulation of cryoprotectants in the enchytraied Enchytraeus albidus (Oligochaeta) from Greenland and Europe
212.  S.V. Petersen, T. Kristensen, J.S. Pedersen, L. Ramsgaard, T.D. Oury, J.D. Crapo, N.C. Nielsen, and J.J. Enghild. J. Biol. Chem. 283, 15031 (2008).
The Folding of Human aEC-SOD and iEC-SOD is an Intracellular Event
211.  O. Hageman, M. Bjerring, N.C. Nielsen, F.C. Krebs. Solar Energy Materials and Solar Cells 92, 1327 (2008).
All solution processed tandem polymer solar cells based on thermocleavable materials
210.  P. Würtz, P. Permi, N. C. Nielsen, and O. W. Sørensen. J. Magn. Reson. 194, 89 (2008).
Clean-HMBC: Suppression of Strong-Coupling Induced Artefacts in HMBC Spectra
209.  M. Ø. Pedersen, J. Underhaug, J. Dittmer, M. Miller, and N. C. Nielsen. FEBS Lett. 582, 2869 (2008).
The three-dimensional structure of CsmA: A small antenna protein from the green sulfur bacterium Chlorobium tepidum
208.  A. S. P. Svane, K. Jahn, T. Devaa, A. Malmendal, D. Otzen, J. Dittmer, and N. C. Nielsen. Biophys. J. 95, 366 (2008).
Early Stages of Amyloid Fibril Formation Studied by Liquid-State NMR: The Peptide Hormone Glucagon
207.  I. Maximov, Z. Tosner, and N. C. Nielsen. J. Chem. Phys. 128, 184505-1 (2008).
Optimal Control Design of NMR and DNP Experiments using Monotonically Convergent Algorithms
206.  M. L. H. Mantel, L. S. Søbjerg, T. H. V. Huynh, J.-P. Ebran, A. T. Lindhardt (né Hansen), N. C. Nielsen, and T. Skrydstrup. J. Org. Chem. 73, 3570 (2008).
An expedient synthesis of the fibril binding compound FSB via sequential Pd-catalysed coupling reactions
205.  L. Thøgersen, B. Schiøtt, T. Vosegaard, N. C. Nielsen, and E. Tajkhorshid. Biophys. J. 95, 4337 (2008).
Peptide Aggregation and Pore Formation in a Lipid Bilayer - A Combined Coarse Grained and All Atom Molecular Dynamics Study
204.  L. Celik, S. Sinning, K. Severinsen, C. G. Hansen, M. S. Møller, M. Bols, O. Wiborg, and B. Schiøtt. J. Am. Chem. Soc. 130, 3852 (2008).
Binding of serotonin to the human serotonin transporter. Molecular modelling and experimental validation.
203.  A. T. Lindhardt, M. L. H. Mantel, and T. Skrydstrup. null 47, 2668 (2008).
Intermolecular Enyne Isomerization: Development of an Atom Efficient Mizoroki-Heck Type Coupling
202.  K. Andersen, P. Westh, and D. E. Otzen. 15, 399 (2008).
A global study of myoglobinsurfactant interactions. Amyloid-like adhesins in floc-forming and filamentous bacteria in activated sludge.
201.  P. Larsen, J. L. Nielsen, D. E. Otzen, and P. H. Nielsen. 74, 1517 (2008).
Amyloid-like adhesins in floc-forming and filamentous bacteria in activated sludge.
200.  D. E. Otzen, L. Nesgaard, K. K. Andersen, J. H. Hansen, G. Christiansen, H. Doe, and P. Sehgal. Biochim. Biophys. Acta 1784, 400 (2008).
Aggregation of S6 in a quasi-native state by monomeric SDS.
199.  P. Sehgal, D. Sharma, K. L. Larsen, R. Wimmer, D. E. Otzen, and H. Doe. 29, 128 (2008).
Influence of beta-Cyclodextrin on the Mixed Micellization Process of Sodium Dodecyl Sulfate and Sodium Lauroyl Sarcosine and Formation of Inclusion Complexes.
198.  M. Thaysen-Andersen, I. B. Thøgersen, U. Lademann, H. Offenberg, A. M. Giessing, J. J. Enghild, H. J. Nielsen, N. Brünner, and P. Højrup. Biochim. Biophys. Acta 1784, 455 (2008).
Investigating the biomarker potential of glycoproteins using comparative glycoprofiling - application to tissue inhibitor of metalloproteinases-1.
197.  C. R. Kliment, J. M. Tobolewski, M. L. Manni, R. J. Tan, J. J. Enghild, and T. D. Oury. 2, 261 (2008).
Extracellular superoxide dismutase protects against matrix degradation of heparan sulfate in the lung.
196.  H. J. Hoffmann, L. M. Tabaksblat, J. J. Enghild, and R. Dahl. 2, 380 (2008).
Human skin keratins are the major proteins in exhaled breath condensate
195.  N. Mallorquí-Fernández, S. P. Manandhar, G. Mallorquí-Fernández, I. Usón, K. Wawrzonek, T. Kantyka, M. Solà, I. B. Thøgersen, J. J. Enghild, J. Potempa, and F. X. Gomis-Rüth. J. Biol. Chem. 283, 2871 (2008).
A new autocatalytic activation mechanism for cysteine proteases revealed by Prevotella intermedia interpain A
194.  J. Jacobsen, R. Visse, H. P. Sørensen, J. J. Enghild, K. Brew, U. M. Wewer, and H. Nagase. Biochemistry 47, 535 (2008).
Catalytic properties of ADAM12 and its domain deletion mutants.
193.  L. Celik, B. Schiøtt, and E. Tajkhorshid . Biophys. J. 94, 1600 (2008).
Substrate binding and formation of an occluded state in the leucine transporter.
192.  P. A. Christensen, J. S. Pedersen, G. Christiansen, and D. E. Otzen. FEBS Lett. 582, (2008).
Spectroscopic evidence for the existence of an obligate pre-fibrillar oligomer during glucagon fibrillation.
191.  S. K. Knudsen, A. Stensballe, M. Franzmann, U. B. Westergaard, and D. E. Otzen. Brain 412, 563 (2008).
Effect of glycosylation on the extracellular domain of the Ag43 bacterial autotransporter: enhanced stability and reduced cellular aggregation.
190.  M. A. Lie and B. Schiøtt . null 29, 1037 (2008).
A Density Functional Study of Solvation Effects on the Tautomeric Equilibrium and Ylide Generation in Thiamin Diphosphate,
189.  N. A. Afshari, R. P. Bahadur, D. E. Eifrig Jr., I. B. Thøgersen, J. J. Enghild, and G. K. Klintworth . 12, 495 (2008).
Atypical asymmetric lattice corneal dystrophy associated with a novel homozygous mutation (Val624Met) in the TGFBI gene
188.  G. Dubin, J. Stec-Niemczyk, M. Kisielewska, K. Pustelny, G. M. Popowicz, M. Bista, T. Kantyka, K. T. Boulware, H. R. Stennicke, A. Czarna, M. Phopaisam, P. S. Daugherty, I. B. Thøgersen, J. J. Enghild, N. Thornberry, A. J. Dubin, and J. Potempa. J. Mol. Biol. 379, 343 (2008).
Enzymatic activity of the Staphylococcus aureus SplB serine protease is included by substrates containing the sequence Trp-Glu-Leu-Gln
187.  K. W. Sanggaard, C. S. Sonne-Schmidt, T. P. Krogager, K. A. Lorentzen, H. G. Wisniewski, I. B. Thøgersen, and J. J. Enghild. J. Biol. Chem. 283, 18530 (2008).
The transfer of heavy chains from bikunin proteins to hyaluronan requires both TSG-6 and HC2
186.  J. M. Englert, L. Ramsgaard, Z. Valnickova, J. J. Enghild, and T. D. Oury. Prot. Exp. Purific. 61, 99 (2008).
Large scale isolation and purification of soluble RAGE from lung tissue
185.  D. E. Otzen. 64, 223 (2008).
Differential adsorption of variants of the Thermomyces lanuginosus lipase on a hydrophobic surface suggests a role for local flexibility
184.  P. Sehgal, M. Sharma, K. L. Larsen, R. Wimmer, H. Doe, and D. E. Otzen. 29, 885 (2008).
Interactions of gamma-Cyclodextrin with the Mixed Micelles of Anionic Surfactants and Their Inclusion Complexes Formation
183.  M. Dong, M. B. Hovgaard, W. Mamdouh, S. Xu, D. E. Otzen, and F. Besenbacher. 19, 384013 (2008).
AFM-based force spectroscopy measurements on mature amyloid fibrils of the peptide glucagon
182.  P. Sehgal, O. Kosaka, H. Doe, R. Tanaka, and D. E. Otzen. in press, (2008).
Interaction and stability of mixed micelle and monolayer of nonionic and cationic surfactant mixtures
181.  L. Nielsen and T. Skrydstrup. in press, (2008).
Sequential C–Si Bond Formations From Diphenylsilane: Application to Silanediol Peptide isostere Precursors
180.  A. Croft, K. B. Lindsay, P. Renaud, and T. Skrydstrup . in press, (2008).
Efficient Synthesis of Biomolecules with Radical Chemistry.
179.  Z. Nourian, M.J. Mulvany, K.B. Nielsen, D.S. Pichering, and T. Kristensen. in press, (2008).
The Antagonistic Effect of Antipsychotic Drugs on HEK293 Cell Line Stably Expressing Human a1A1-Adrenoceptors
178.  Langlas, L., Valnickova, Z., Arolas, J. L., Pallarés, I., Guevara, T., Solà, M., Kristensen, T., Enghild, J.J., Aviles, F. X., and Gomis-Rüth. in press, (2008).
Structure of Activated Thrombin-Activatable Fibrinolysis Inhibitor, a Molecular Link between Coagulation and Fibrinolysis
177.  K. Andersen, I. Pallares, Z. Valnickova, T. Christensen, J. Vendrell, K. U. Wendt, H. A. Schreuder, J. J. Enghild, and F. X. Avilés. J. Biol. Chem. in press, (2008).
The crystal structure of TAFI provides the structural basis for its intrinsic activity and the short half-life of TAFIa
176.  T. M. Gøgsig, L. S. Søbjerg, A. T. Lindhardt, K. L. Jensen, and T. Skrydstrup. J. Org. Chem. 73, 3404 (2008).
Direct Vinylation and Dipfluorovinylation of Arylboronic Acids Using Vinyland 2,2-Difluorovinyl Tosylates via the Suzuki-Miyaura Cross Coupling.
175.  A. T. Lindhardt and T. Skrydstrup. asap, (2008).
New Surprises in Palladium-Catalyzed C–C Coupling Reactions.
174.  K. S. Pedersen, T. N. Kristensen, V. Loeschcke, B. O. Pedersen, J. Ø. Duus, N. C. Nielsen and A. Malmendal. Genetics 180, 1233 (2008).
173.  L. Giehm, C. Christensen, U. Boas, P. M. H. Heegaard, and D. E. Otzen . 89, 522 (2008).
Dendrimers destabilize proteins in a generation-dependent manner involving electrostatic interactions
172.  L. Nesgaard, A. Malmendal, S. V. Hoffmann, and D. E. Otzen. 89, 779 (2008).
Characterization of Dry Globular Proteins and Proteins Fibrils by Synchrotron Radiation Circular Dichroism
171.  D. E. Otzen and P. H. Nielsen. Cell Mol. Life Sci. 65, 910 (2008).
We find them here, we find them there: Functional bacterial amyloid.
170.  J. S. Pedersen and D. E. Otzen. Protein Sci. 17, 1 (2008).
Amyloid - A state in many guises: survival of the fittest fibril fold.
169.  H. Karring, T. Møller-Pedersen, J. J. Enghild, G. K. Klintworth. in Pathobiology of Ocular Disease, Ed. Garner and Klintworth (2008).
Ocular Proteins and Proteomics
168.  S. Haaning, S. Radutoiu, S.V. Hoffmann, J. Dittmer, L. Giehm, D.E. Otzen, and J. Stougaard. J. Biol. Chem. 283, 31142 (2008).
An unusual intrinsically disordered protein from the model legume Lotus japonicus stabilizes proteins in vitro
 
2007
167.  K. Bertelsen, J. M. Pedersen, N. C. Nielsen, and T. Vosegaard. J. Magn. Reson. 184, 273 (2007).
2D separated-local field spectra from projections of 1D experiments
166.  D. E. Otzen, L. Giehm, R. P. Baptista, S. R. Kristensen E. P. Melo, and S. Pedersen. Biochim. Biophys. Acta 1774, 323 (2007).
Aggregation as the basis for com?lex behaviour of cutinase in different denaturants
165.  C. Kehlet, M. Bjerring, A.C. Sivertsen, T. Kristensen, J.J. Enghild, S.J. Glaser, N. Khaneja, N.C. Nielsen . J. Magn. Reson. 188, 216 (2007).
Optimal control based NCO and NCA experiments for spectral assignment in biological solid-state NMR spectroscopy
164.  A.C. Sivertsen, M. Gasior, M. Bjerring, S.U. Hansen, O.L. Lopez, N.C. Nielsen, M. Bols. European Journal of Organic Chemistry 11, 1735 (2007).
Active Site Protonation of 1-Azafagomine in Glucosidases Studied by Solid-State NMR Spectroscopy
163.  J. Ø. Hansen, C. Kehlet, M. Bjerring, T. Vosegaard, S. J. Glaser, N. Khaneja, and N. C. Nielsen. Chem. Phys. Lett. 447, 154 (2007).
Optimal control based design of composite dipolar recoupling experiments by analogy to single-spin inversion pulses
162.  W. Russel Bowman, Anthony J. Fletcher, Jan M. Pedersen, Peter J. Lovell, Mark R. J. Elsegood, Elena Hern?ndez L?pez, Vikcki McKee, and Grame B. S. Potts. Tetrahedron 63, 191 (2007).
Amides as precursors of imidoyl radicals in cyclisation reactions
161.  Z. Valnickova, S. V. Petersen, S. B. Nielsen, D. E. Otzen, and J. J. Enghild. J. Biol. Chem. 282, 6661 (2007).
Heparin binding induces a conformational change of pigment epithelium-derived factor
160.  T. Vosegaard and D. Massiot. Chem. Phys. Lett. 437, 120 (2007).
High-resolution two-dimensional NMR spectra of half-integer-spin quadrupolar nuclei from one-dimensional projections
159.  P. Sehgal, D. Sharma, K. L. Larsen, R. Wimmer, D. E. Otzen, and H. Doe. J. Disp. Sci. Tech in press, (2007).
Influence of beta-Cyclodextrin on the Mixed Micellization Process of Sodium Dodecyl Sulfate and Sodium Lauroyl Sarcosine and Formation of Inclusion Complexes
158.  D. E. Otzen and L. Nesgaard. Biochemistry 46, 4348 (2007).
Alternative membrane protein conformations in alcohols
157.  M. M. Nielsen, K. Andersen, P. Westh, and D. E. Otzen. Biophysical Journal 92, 3674 (2007).
Unfolding of beta-sheet proteins in SDS
156.  J. E. Mogensen, M. Ferreras, S. V. Petersen, J. J. Enghild, and D. E. Otzen. Biochemistry 46, 3356 (2007).
The major allergen from birch tree pollen, Bet v 1, is a membrane binding protein
155.  P. Larsen, M. Dueholm, G. Christianse, J. L. Nielsen, D. E. Otzen, and P. H. Nielsen. Env. Microbiol. 9, 3077 (2007).
Aggregative fimbriae are abundant in natural biofilms
154.  M. B. Hovgaard, M. Dong, D. E. Otzen, and F. Besenbacher. Biophysical Journal 93, 2162 (2007).
Quartz Crystal Microbalance studies of multi-layer glucagon fibrillation at the solid-liquid interface
153.  N. K. Holm, S. K. Jespersen, L. V. Thomassen, T. Y. Wolff, P. Sehgal, L. A. Thomsen, G. Christiansen, A. D. Knudsen, and D E. Otzen. Biochim. Biophys. Acta 1774, 1128 (2007).
Aggregation and fibrillation of bovine serum albumin
152.  P. M. H. Heegaard, U. Boas, and D. E. Otzen. Macromolecular Bioscience 7, 1047 (2007).
Dendrimer Effects on Peptide and Protein Fibrillation
151.  C. B. Andersen, D. E. Otzen, G. Christiansen, and C. Rischel . Biochemistry i46, 7314 (2007).
Glucagon amyloid-like fibril morphology is selected via capping of one fibril type by reversible trimers
150.  S. A. Johannesen, D. Sinou, E. Framery, and T. Skrydstrup. Tetrahedron Lett. 48, 3569 (2007).
Evaluation of disaccharide-based ligands for Pd(0)-catalyzed asymmetric allylations
149.  K. B. Lindsay, F. Ferrando, K. L. Christensen, J. Overgaard, M.-L. Bennasar, and T. Skrydstrup. J. Org. Chem. 72, 4181 (2007).
SmI2-Promoted Radical Addition Reactions with N-(2-Indolylacyl)oxazolidinones: Synthesis of Bisindole Compounds
148.  J. P. Ebran, A. L. Hansen, T. G?gsig, and T. Skrydstrup. J. Am. Chem. Soc. 129, 6931 (2007).
Studies on the Heck Reaction with Alkenyl Phosphates: Can the 1,2-Migration Be Controlled? Scope and Limitations
147.  A. L. Hansen, J. P. Ebran, T. G?gsig, and T. Skrydstrup. J. Org. Chem. 72, 6464 (2007).
Investigations on the Suzuki-Miyaura and Negishi Couplings with Alkenyl Phosphates: Application to the Synthesis of 1,1-Disubstituted Alkenes
146.  J. F. Young, H. C. Bertram, P. K. Theil, A.-G. D. Petersen, K. A. Poulsen, M. Rasmussen, A. Malmendal, N. C. Nielsen, M. Vestergaard, and N. Oksbjerg. Meat Science 76, 342 (2007).
In vitro and in vivo studies of creatine monohydrate supplementation to Duroc and Landrace pigs
145.  H. C. Bertram, A. Malmendal, B. O. Petersen, J. C. Madsen, H. Pedersen, N. C. Nielsen, C. Hoppe, C. M?lgaard, K. F. Michaelsen, and J. ?. Duus. Analytical Chemistry 79, 7110 (2007).
Effect of magnetic field strength on NMR-based metabonomic of human urine data ? A comparative study of 250, 400, 500 and 800 MHz
144.  J. Overgaard, A. Malmendal, J. G. S?rensen, J. G. Bundy, V. Loeschcke, N. C. Nielsen, and M. Holmstrup. J. Insect Physiol 53, 1218 (2007).
Metabolomic profiling of rapid cold hardening and cold shock in Drosophila melanogaster
143.  S. G. Hansen and T. Skrydstrup. Eur. J. Org. Chem. , 3392 (2007).
A Simple Procedure to 3,6-Dibenzoylated Glucosamine Derivatives. Potential Building Blocks for Oligochitosan Synthesis
142.  S. A. Johannesen, B. O. Pedersen, J. ?. Duus, and T. Skrydstrup. Inorg. Chem. 46, 4326 (2007).
Studies Directed to Understanding the Structure of Chitosan-Metal complexes: Investigations of Mono- and Disaccharide Models with Platinum (II) Group Metals
141.  K. Bertelsen, J. M. Pedersen, B. S. Rasmussen, T. Skrydstrup, N. C. Nielsen, and T. Vosegaard. J. Am. Chem. Soc. 129, 14717 (2007).
Membrane-Bound Conformation of Peptaibols with Methyl-Deuterated a-Amino Isobutyric Acids by 2H MAS Solid-State NMR Spectroscopy
140.  T. Mittag, K. B. Lindsay, J. Faber, N. C. Nielsen, and T. Skrydstrup. J. Org. Chem. 72, 10035 (2007).
Stereocontrolled Synthesis of Methyl Silanediol Peptide Mimics
139.  S. V. Petersen, Z. Valnickova, T. D. Oury, J. D. Crapo, N. C. Nielsen, and J. Enghild. BMC Biochemistry 15, 8 (2007).
The Subunit Composition of Human Extracellular Superoxide Dismutate (EC-SOD) Regulate Enzymatic Activity
138.  A. I. S. Holm, P. Hvelplund, U. Kadhane, M. K. Larsen, B. Liu, S. B. Nielsen, S. Panja, J. M. Pedersen, T. Skrydstrup, K. St?chkel, E. R. Williams, and E. S. Worm. J. Phys. Chem. A. 111, 9641 (2007).
On the mechanism of electron-capture induced dissociation of peptide dications from 15N-labeling and crown-ether complexation
137.  L. Nielsen, K. B. Lindsay, J. B. Faber, N. Chr. Nielsen, and Troels Skrydstrup. J. Org. Chem. 72, 10035 (2007).
Stereocontrolled Synthesis of Methyl Silanediol Peptide Mimics
136.  B. S. Rasmussen, J. M. Pedersen, J. S?rensen, J. Egebjerg, B. Schi?tt, K. K. Mortensen, and T. Skrydstrup. ChemBioChem 8, 1974 (2007).
Enantioselective proteins- Selection, binding studies and molecular modelling of antibodies with affinity towards hydrophobic BINOL derivatives
135.  J. Sørensen, H. F. Clausen, R. D. Poulsen, J. Overgaard, B. Schiøtt, and . J. Phys. Chem. 111, 345 (2007).
Short strong hydrogen bonds in 2-acetyl-1,8-dihydroxy-3,6-naphtalene – An outlier to current hydrogen bonding theory?
134.  L. Celik, J. D. D. Lund, and B. Schiøtt. Biochemistry 46, 1743 (2007).
Conformational dynamics of the estrogen receptor a: Influence of binding site structure on ptotein dynamics and biological function studied by MD simulations.
133.  T. K. Dalsgaard, D. E. Otzen, J. H. Nielsen, and L. B. Larsen. J. Agr. Food Chem. 55, 10968 (2007).
Changes in structures of milk proteins upon photo-oxidation
132.  P. Sehgal, S. B. Nielsen, S. Pedersen, R. Wimmer, and D. E. Otzen. Biochim. Biophys. Acta 1774, 1544 (2007).
Modulation of cutinase structure and stability by phospholipid detergents,
131.  Y. J. C. Song, D. M. S. Lundvig, Y. Huang, W. P. Gai, P. C. Blumbergs, P. Højrup, D. E. Otzen, G. M. Halliday, and P. H. Jensen. 171, 1291 (2007).
p25a Relocalizes in Oligodendroglia from Myelin to Cytoplasmic Inclusions in Multiple System Atrophy
130.  H. Karring, Z. Valnickova, I. B. Thøgersen, C. J. Hedegaard, T. Møller-Pedersen, T. Kristensen, G. K. Klintworth, and J. J. Enghild. 13, 997 (2007).
Evidence against a blood derived origin for transforming growth factor beta induced protein in corneal disorders caused by mutations in the TGFBI gene.
129.  C. Gendron, M. Kashiwagi, N. H. Lim, J. J. Enghild, I. B. Thøgersen, C. Hughes, and B. Caterson and H. Nagase. J. Biol. Chem. 282, 18294 (2007).
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
128.  Z. Valnickova, I. B. Thøgersen, J. Potempa, and J. J. Enghild. 6, 1336 (2007).
The intrinsic enzymatic activity of procarboxypeptidase U (TAFI) does not significantly influence the fibrinolytic rate: reply to a rebuttal.
127.  P. P. Lizotte, L. E. Hanford, J. J. Enghild, E. Nozik-Grayck, B. L. Giles, and T. D. Oury. null 7, 15 (2007).
Developmental expression of the receptor for advanced glycation end-products (RAGE) and its response to hyperoxia in the neonatal rat lung.
126.  Z. Valnickova, I. B. Thøgersen, J. Potempa, and J. J. Enghild. J. Biol. Chem. 282, 3066 (2007).
Thrombin-activable fibrinolysis inhibitor (TAFI) zymogen is an active carboxypeptidase.
125.  M. J. Nielsen, S. V. Petersen, C. Jacobsen, S. Thirup, J. J. Enghild, J. H. Graversen, and S. K. Moestrup . J. Biol. Chem. 282, 1072 (2007).
A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex.
124.  C. F. Bisgaard, M. N. Jayatissa, J. J. Enghild, C. Sanchez, R. Artemychyn, and O. Wiborg. 32, 132 (2007).
Proteomic investigation of the ventral rat hippocampus links DRP-2 to escitalopram treatment resistance and SNAP to stress resilience in the chronic mild stress model of depression.
123.  H. S. Christensen, S. V. Boye, J. Thinggaard, S. Sinning, O. Wiborg, B. Schiøtt, and M. Bols. 15, 5262 (2007).
QSAR studies and pharmacophore identification for arylsubstituted cycloalkencarboxylic acid methyl esters with affinity for the humane dopamine transporter
122.  G. K. H. Madsen, G. J. McIntyre, B. Schiøtt, and F. K. Larsen. Chem. Eur. J 13, 5539 (2007).
The Low-Barrier Hydrogen Bond probed by Low Temperature neutron and X-Ray Diffraction of Deuterated Benzoylacetone,
121.  J. Sørensen, D. Hammelberg, B. Schiøtt, and J. A. McCammon. Biopolymers (Biospectroscopy) 86, 73 (2007).
Comparative MD analysis of the stability of transthyretin providing insight into the fibrillation mechanism.
120.  K. Runager, J. J. Enghild, and G. K. Klintworth. , (2007).
Focus on molecules: Transforming growth factor beta induced protein
119.  H. C. Bertram, K. E. Bach Knudsen, A. Malmendal, N. C. Nielsen, X. Fretté, and H. J. Andersen. in “Magnetic Resonance in Food Science: From Molecules to Man”, Ed. I. A Farhat, P.S. Belton, and G. A. (2007).
1H NMR-Based Metabonomics Applied in the Elucidation of Biochemical Effects of Consumption of Whole Grain Cereals
 
2006
118.  J. Underhaug, L. Odgaard Jakobsen, A. Malmendal, P. Fojan, M. Esmann, and N. C. Nielsen. FEBS Lett. 580, 4777 (2006).
NMR studies of the Fifth Transmembrane Segment of Na+,K+-ATPase Reveals a Non-Helical Ion-Binding Region
117.  N. C. Nielsen, T. Vosegaard, and A. Malmendal. in Handbook of Magnetic Resonance, Ed. (2006).
Analytical and Numerical Tools for Experiment Design in Solid-State NMR Spectroscopy
116.  H.C. Bertram, K.E.B. Knudsen, A. Serana, A. Malmendal, N.C. Nielsen, X.C. Frett? and H.J. Andersen. British J. Nutrition 5, 955 (2006).
NMR-based Metabonomic Studies Reveal Changes in the Biochemical Profile of Plasma and Urine from Pigs Fed High Fiber a Rye Bread
115.  C. Kehlet and N.C. Nielsen. Bruker Report 157, 31 (2006).
Solid-State NMR Experiments by Optimal Control
114.  N. Khaneja, C. Kehlet, S. J. Glaser, and N. C. Nielsen. J. Chem. Phys. 124, 114503-1 (2006).
Composite Dipolar Recoupling: Anisotropy Compensated Coherence Transfer in Solid-State NMR
113.  J. Dittmer and G. Bodenhausen. ChemPhysChem 7, 831 (2006).
Quenching echo modulations in NMR
112.  A. Malmendal, J. Overgaard, J. G. Bundy, J. G. S?rensen, N. C. Nielsen, V. Loeschcke, M. Holmstrup. American Journal of Physiology 291, 205 (2006).
Metabolomic Profiling of Heat Stress: Hardening and Recovery of Homeostasis in Drosophila
111.  A. Malmendal, J. Overgaard, J. G. Bundy, J. G. S?rensen, N. C. Nielsen, V. Loeschcke, and M. Holmstrup. American Journal of Physiology 291, 205 (2006).
Metabolomic Profiling of Heat Stress: Hardening and Recovery of Homeostasis in Drosophila
110.  H. C. Bertram, K. E. B. Knudsen, A. Malmendal, N. C. Nielsen, X. C. Frett?, and H. J. Andersen. British J. Nutrition 5, 955 (2006).
NMR-based Metabonomic Studies Reveal Changes in the Biochemical Profile of Plasma and Urine from Pigs Fed High Fiber a Rye Bread
109.  R. Wimmer, K. Andersen, M. Davidsen, S. M?lgaard, B. Vad, and D. E. Otzen. Biochemistry 45, 481 (2006).
Versatile interactions of the antimicrobial peptide Novispirin with detergents and lipids
108.  P. Sehgal, M. Sharma, R. Wimmer, K. L. Larsen, and D. E. Otzen. Colloid Polymer Sci 284, 916 (2006).
Interactions between Anionic Mixed Micelles and their Inclusion Complexes: Conductivity, NMR and Fluorescence study
107.  P. Sehgal and D. E. Otzen. Protein Sci. 15, 890 (2006).
Thermodynamics of unfolding of an integral membrane protein in mixed micelles
106.  J. S. Pedersen, D. Dikov, J. L. Flink, H. A. Hjuler, G. Christiansen D. E., and Otzen. Biophysical Journal in press, (2006).
Hofmeister salts and glucagon fibrillation: Stabilizing effects of divalent anions
105.  J. S. Pedersen, D. Dikov, J. L. Flink, H. A. Hjuler, G. Christiansen, and D. E. Otzen. J. Mol. Biol. 355, 501 (2006).
The changing face of glucagon fibrillation: Structural polymorphism and conformational imprinting
104.  B. L. Chen, J. A. B. Ferreira, S. M. B. Costa, G. J. M. Cabrita, D. E. Otzen, and E. P. Melo. Biochemistry 45, 2189 (2006).
Compaction of ribosomal protein S6 by sucrose occurs only under native conditions
103.  O. N. Bakharev, D. Bono, H. B. Brom, A. Schepf, H. Schn?ckel, and L. J. de Jongh. Phys. Rev. Lett. 96, 117002 (2006).
Superconductivity in a molecular metal cluster compound
102.  P. Wenter, G. Bodenhausen, J. Dittmer, and S. Pitsch. J. Am. Chem. Soc. 128, 7579 (2006).
Kinetics of RNA Refolding in Dynamic Equilibrium by 1H-Detected 15N Exchange NMR Spectroscopy
101.  L. O. Jakobsen, A. Malmendal, N. C. Nielsen, and M. Esmann. Biochemistry 45, 10768 (2006).
Cation binding in Na,K-ATPase investigated using 205Tl solid-state NMR spectroscopy.
100.  J. K. Jensen, A. Malmendal, B. Schi?tt, S. Skeldal, K. E. Petersen, L. Celik, N. C. Nielsen, P. A. Andreasen, and T. Wind. Biochemical Journal 399, 387 (2006).
Inhibition of Plasminogen Activator Inhibitor-1 Binding to Endocytosis Receptors of the low Density Lipoprotein Receptor Family by a Peptide Isolated from a Phage Displayed Library
99.  Z. Tosner, S. J. Glaser, N. Khaneja, and N. C. Nielsen. J. Chem. Phys. 125, 184502-1 (2006).
Effective Hamiltonians by Optimal Control: Solid-State NMR Double-Quantum and Isotropic Dipolar Recoupling
98.  N. C. Nielsen. in , Ed. (2006).
Effective Hamiltonian Description of Dipolar Re- and Decoupling in Solid-State NMR Spectroscopy
97.  J. Underhaug, L. Odgaard Jakobsen, A. Malmendal, P. Fojan, M. Esmann, and N. C. Nielsen. FEBS Lett. 580, 4777 (2006).
NMR studies of the Fifth Transmembrane Segment of Na+,K+-ATPase Reveals a Non-Helical Ion-Binding Region
96.  J. S. Pedersen, D. Dikov, and D. E. Otzen. Biochemistry 45, 14503 (2006).
N- and C-terminal hydrophobic patches are involved in fibrillation of glucagon.
95.  J. S. Pedersen, D. Dikov, J. L. Flink, and D. E. Otzen. Biophysical Journal 90, 4181 (2006).
Sulfates dramatically stabilize a salt dependent type of glucagon fibrils.
94.  C. Finger, T. Volkmer, A. Prod?hl, D. E. Otzen, D. M. Engelman, and A. Schneider. J. Mol. Biol. 358, 1221 (2006).
The Stability of Transmembrane Helix Interactions Measured in a Biological Membrane.
93.  J. Larsen, R. J. Enem?rke, T. Skrydstrup, and K. Daasbjerg. Organometallics 25, 2031 (2006).
Characterization of HMPA-coordinated TiIII Species in Solutions of Zn-reduced Titanocene Dihalides
92.  K. B. Lindsay and T. Skrydstrup. J. Org. Chem. 71, 4766 (2006).
Formal Total Synthesis of the Potent Renin Inhibitor, Aliskiren: Application of a SmI2-Promoted Acyl-like Radical Coupling
91.  J. P. Ebran, C. M. Jensen, S. A. Johannesen, J. Karaffa, K. B. Lindsay, R. Taaning, and T. Skrydstrup. Organic and Biomolecular Chemistry 4, 3553 (2006).
Creating carbon-carbon bonds with samarium diiodide for the synthesis of modified amino acids and peptides
90.  J. Karaffa, K. B. Lindsay, and T. Skrydstrup. J. Org. Chem. 71, 8219 (2006).
Expanding the Scope of the Acyl-type Radical Addition Reactions Promoted by SmI2
89.  A. L. Hansen, J. P. Ebran, T. G?gsig, and T. Skrydstrup. Chem. Commun. , 4137 (2006).
Direct synthesis of 1,1-diaryl alkenes from alkenyl phosphates via nickel(0)-catalysed Suzuki-Miyaura coupling
88.  S. G. Hansen and T. Skrydstrup. Encyclopedia on Reagents for Organic Synthesis in press, (2006).
(S)-4-Benzyl-2-oxazolidinone
87.  S. Pedersen, L. W. Nesgaard, R. P. Baptista, E. P. Melo, S. R. Kristensen, and D. E. Otzen. Biopolymers 83, 619 (2006).
pH-dependent aggregation of cutinase is efficiently suppressed by 1,8-ANS
86.  M. Dong, M. B. Hovgaard, S. Xu, and D. E. Otzen. 17, 1 (2006).
AFM study of glucagon fibrillation via oligomeric structures resulting in interwoven fibrils
85.  A. L. Hansen, J. P. Ebran, M. Ahlquist, P. O. Norrby, and T. Skrydstrup. Angew. Chem. Int. Ed. 45, 3349 (2006).
Heck Coupling with Nonactivated Alkenyl Tosylates and Phosphates. Examples of Effective 1,2-Migrations of the Alkenyl Palladium (II) Intermediates
84.  K. W. Sanggaard, C. S. Sonne-Schmidt, C. Jacobsen, I. B. Thøgersen, Z. Valnickova, H. G. Wisniewski, and J. J. Enghild. Biochemistry 45, 7661 (2006).
Evidence for a two-step mechanism involved in the formation of covalent HC x TSG-6 complexes.
83.  A. V. Due, S. V. Petersen, Z. Valnickova, L. Østergaard, T. D. Oury, J. D. Crapo, and J. J. Enghild.. Biochemistry 580, 1485 (2006).
Extracellular superoxide dismutase exists as an octamer.
82.  Z. Valnickova, T. Christensen, P. Skottrup, I. B. Thøgersen, P. Højrup, and J. J. Enghild.. Biochemistry 45, 1525 (2006).
Post-translational modifications of human thrombin-activatable fibrinolysis inhibitor (TAFI): evidence for a large shift in the isoelectric point and reduced solubility upon activation.
81.  S. G. Hansen and T. Skrydstrup. in Modification of Carbohydrates, Amino Acids and Peptides Via Radical Reactions, Ed. (2006).
Current Topics in Chemistry
 
2005
80.  A.C. Sivertsen, M. Bjerring, C.T. Kehlet, T. Vosegaard, N.C. Nielsen. Annu. Rep. NMR Spectrosc. 54, 243 (2005).
Numerical Simulations in Biological Solid-State NMR Spectroscopy
79.  M. Kamihira, T. Vosegaard, A. J. Mason, S. Straus, N. C. Nielsen, and A. Watts. J. Struct. Biol. 149, 7 (2005).
Structural and orientational constraints of bacteriorhodopsin in purple membranes determined by oriented-sample solid-state NMR spectroscopy
78.  E. Lindersson, D. Lundvig, C. Petersen, P. Madsen, J. R. Nyengaard, P. H
ojrup, T. Moos, D. E. Otzen, W.-P. Gai, P. C. Blumbergs, and P. H. Jensen. J. Biol. Chem. 280, 5703 (2005).
P25a is co-expressed with alpha-synuclein in alpha-synucleinopathies and stimulates its aggregation
77.  A. Malmendal, C. W. Vander Kooi, N. C. Nielsen, and W. Chazin. Biochemistry 44, 6502 (2005).
Calcium-modulated S100 protein-phospholipic interactions. An NMR study of calbindin D9k and DPC
76.  H. C. Bertram, N. B. Kristensen, A. Malmendal, N. C. Nielsen, R. Bro, H. J. Andersen, and D. L. Harmon. Analytica Chimica Acta 536, 1 (2005).
A metabolomic investigation of splanchnic metabolism using 1H NMR spectroscopy of bovine blood plasma
75.  C. T. Kehlet, T. Vosegaard, N. Khaneja, S. J. Glaser, and N. C. Nielsen. Chem. Phys. Lett. 414, 204 (2005).
Low-power homonuclear dipolar recoupling in solid-state NMR developed using optimal control theory
74.  T. Vosegaard, C. T. Kehlet, N. Khaneja, S. J. Glaser, and N. C. Nielsen. J. Am. Chem. Soc. 127, 13768 (2005).
Improved excitation schemes for multiple-quantum magic-angle spinning for quadrupolar nuclei designed using optimal control theory
73.  K. W. Sanggaard, H. Karring, I. B. Th?gersen, Z. Valnickova, and J. J. Enghild . J. Biol. Chem. 280(12), 11936 (2005).
The TSG-6 and IaI interaction cleaves the IaI protein-glycosaminoglycan-protein (PGP) cross-link. Evidence for reorganization of the IaI subunits during complex formation
72.  H. Karring, I. B. Th?gersen, G. K. Klintworth, T. M?ller-Pedersen, and J. J. Enghild . Mol Cell Proteomics. 4, 1406 (2005).
A dataset of human cornea proteins identified by peptide mass fingerprinting and tandem mass spectrometry
71.  P. Sehgal, J. E. Mogensen, and D. E. Otzen. Biochim. Biophys. Acta 1761, 59 (2005).
Using micellar mole fractions to assess membrane protein stability in mixed micelles
70.  P. Sehgal, H. Doe, M. Sharma, and D. E. Otzen. Colloid Polymer Sci 382, 1219 (2005).
Synergistic behavior of sodium dodecyl sulfate and 1,2-diheptanoyl-sn-glycero-3-phosphocholine in an aqueous medium: Interfacial and bulk behaviour
69.  L. Y. Chen, G. J. M. Cabrita, D. E. Otzen, and E. Pinho e Melo. J. Mol. Biol. 351, 402 (2005).
Stabilization of the ribosomal protein S6 by trehalose is counterbalanced by the formation of a putative off-pathway species
68.  S. Frokjaer and D. E. Otzen. Nat. Rev. Drug. Delivery 4, 298 (2005).
Protein drug stability - a formulation challenge
67.  D. E. Otzen. Trends in Drug Discovery 6, 2 (2005).
Protein aggregation and fibrillation: Problems and Prospects
66.  D. E. Otzen, D. Lundvig, R. Wimmer, L. Hatting, J. R. Pedersen, and P. H. Jensen. Protein Sci. 14, 1396 (2005).
p25alpha is flexible but natively folded and binds tubulin in an oligomeric complex
65.  J. E. Mogensen and D. E. Otzen. Mol. Microbiol. 57, 326 (2005).
Interactions between periplasmic chaperones and bacterial outer membrane proteins
64.  J. . Mogensen, J. H. Kleinschmidt, M. A. Schmidt, and D. E. Otzen . Prot. Sci. In press 14, 2814 (2005).
Misfolding of a Bacterial Autotransporter
63.  J. S. Pedersen, D. Dikov, J. L. Flink, H. A. Hjuler, G. Christiansen, and D. E. Otzen. Biophysical Journal , (2005).
Hofmeister salts and glucagon fibrillation: Stabilizing effects of divalent anions
62.  D. E. Otzen. Biochim. Biophys. Acta 1750, 146 (2005).
Expansion during folding of a collapsed state
61.  J. S. Pedersen, D. Dikov, J. L. Flink,, H. A. Hjuler, G. Christiansen, and D. E. Otzen. J. Mol. Biol. , (2005).
The changing face of glucagon fibrillation: Structural polymorphism and conformational imprinting
60.  J. E. Mogensen, D. Tapadar, M. A. Schmidt, and D. E. Otzen. Biochemistry 44, 4533 (2005).
Barriers to folding of the Transmembrane Domain of the Escherichia coli Autotransporter Adhesin involved in diffuse adherence
59.  D. E. Otzen. Prot. Eng. Design Select 18, 547 (2005).
Antagonism and non-native interactions in S6 probed by double-mutant cycle analysis
58.  P. Berkowitz, P. Hu, Z. Liu, L. A. Diaz, J. J. Enghild, and M. P. Chua D. S. Rubenstein . J. Biol. Chem. 280(25), 23778 (2005).
Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization
57.  S. V. Petersen and J. J. Enghild . Biomed Pharmacother 59, 175 (2005).
Extracellular superoxide dismutase: structural and functional considerations of a protein shaped by two different disulfide bridge patterns
56.  S. V. Petersen, D. A. Olsen, J. M. Kenney, T. D. Oury, Z. Valnickova, I. B. Thogersen, J. D. Crapo, and J. J. Enghild. Biochemical Journal 385, 427 (2005).
The high concentration of Arg213->Gly extracellular superoxide dismutase (EC-SOD) in plasma is caused by a reduction of both heparin and collagen affinities
55.  N. Halland, M. A. Lie, A. Kj?rsgaard, M. Marigo, B. Schi?tt, and K. A. J?rgensen. Chem. Eur. J , (2005).
Mechanistic Insight into the 2,5-Diphenylpyrrolidine Catalyzed Enantioselective alpha-Chlorination of Aldehydes
54.  M. A. Lie, L. Celik, K. A. J?rgensen, and B. Schi?tt. Biochemistry , (2005).
Cofactor Activation and Substrate Binding in Pyruvate Decarboxylase; Insights to the reaction Mechanism from molecular Dynamics Simulations
53.  K. B. Lindsay and T. Skrydstrup. in , Ed. (2005).
2-Pyridinethiol
52.  R. J. Enem?rke, J. Larsen, T. Skrydstrup, and K. Daasbjerg. Organometallics 24, 1252 (2005).
Influence of the Halogen in Titanocene Halide Promoted Reductions
51.  C. M. Jensen, K. B. Lindsay, R. H. Taaning, J. Karaffa, A. M. Hansen, and T. Skrydstrup. J. Am. Chem. Soc. 127, 6544 (2005).
Can Decarbonylation of Acyl Radicals Be Overcome in Radical Addition Reactions? En Route to a Solution Employing N-Acyl Oxazolidinones and SmI2/H2O
50.  A. L. Hansen and T. Skrydstrup. J. Org. Chem. 70, 5997 (2005).
Fast and Regioselective Heck Couplings with N-Acyl-N-vinylamine Derivatives
49.  C. M. Jensen, K. B. Lindsay, P. Andreasen, and T. Skrydstrup. J. Org. Chem. 70, 7512 (2005).
Synthesis of a Hydroxyethylene Isostere of the Tripeptide Arg-Gly-Leu via a Convergent Acyl-like Radical Addition Strategy
48.  A. Gavrila, L. Andersen, and T. Skrydstrup. Tetrahedron Lett. 46, 6205 (2005).
A convenient and simple procedure for the preparation of nitrate esters from alcohols employing LiNO3/(CF3CO)2O
47.  J.-P. Ebran, R. G. Hazell, and T. Skrydstrup. Chem. Commun. , 5402 (2005).
Samarium diiodide-induced intramolecular pinacol coupling of dinitrones: Synthesis of cyclic cis-vicinal diamines
46.  A. L. Hansen and T. Skrydstrup. Org. Lett. 7, 5585 (2005).
Regioselective Heck Couplings of /alpha,/beta-Unsaturated Tosylates and Mesylates with Electron Rich Olefins
45.  S. G. Hansen and T. Skrydstrup. Current Topics in Chemistry , (2005).
Modification of Carbohydrates, Amino Acids and Peptides Via Radical Reactions
44.  S. V. Petersen, D. A. Olsen, J. M. Kenney, T. D. Oury, Z. Valnickova, I. B. Thogersen, J. D. Crapo, and J. J. Enghild. Biochemical Journal 385, 427 (2005).
The high concentration of Arg213->Gly extracellular superoxide dismutase (EC-SOD) in plasma is caused by a reduction of both heparin and collagen affinities
43.  S. Cavadini, J. Dittmer, S. Antonijevic and G. Bodenhausen. J. Am. Chem. Soc. 127, 15744 (2005).
Slow diffusion by singlet-state NMR spectroscopy
42.  Jan M. Pedersen, W. Russel Bowman, Mark R. J. Elsegood, and Anthony J. Fletcher and Peter J. Lovell . J. Org. Chem. 70, 10615 (2005).
Synthesis of ellipticine ? a radical cascade protocol to aryl- and heteroaryl annulated[b]carbazoles
41.  J. E. Mogensen, P. Sehgal, and D. E. Otzen. Biochemistry 44, 1719 (2005).
Activation, inhibition and destabilization of Thermomyces lanuginosus lipase by detergents.
 
2004
40.  T. Vosegaard and N. C. Nielsen. Magn. Reson. Chem. 42, 285 (2004).
Improved pulse sequences for pure exchange solid-state NMR spectroscopy
39.  B. Schi?tt, J. Overgaard, F. K. Larsen, and B. B. Iversen. J. Quantum. Chem. 96, 23 (2004).
Testing Theory Beyond Molecular Structure: Electron Density Distributions of Complex Molecules
38.  B. Schi?tt. J. Quantum. Chem. 99, 61 (2004).
On the Possible Involvement of Collective Domain Movement in the Catalytic Reaction of Soluble Epoxide Hydrolase
37.  B. Schi?tt. Chem. Commun. , 498 (2004).
The Influence of Solvation on the Asp-His Interaction in Subtilisins. Insights from a Density Functional Theory Study
36.  D. Siminovitch, T.S. Untidt, and N.C. Nielsen. J. Chem. Phys. 120, 51 (2004).
Exact effective Hamiltonian theory. II: Expansion of matrix functions and entangled unitary exponential operators.
35.  N.C. Nielsen, A. Malmendal, and T. Vosegaard. Mol. Membr. Biol. 21, 129 (2004).
Techniques and Applications of NMR to Membrane Proteins
34.  C.T. Kehlet, A.C. Sivertsen, M. Bjerring, T.O. Reiss, N. Khaneja, S.J. Glaser, N.C. Nielsen. J. Am. Chem. Soc. 126, 10202 (2004).
Improving Solid-State NMR Dipolar Recoupling by Optimal Control
33.  N.C. Nielsen. in NMR in Biological Systems, Ed. (2004).
Computational Aspects of Biological Solid-State NMR Spectroscopy
32.  H.C. Bertram, N.B. Kristensen, A. Malmendal, N.C. Nielsen, S.K. Jensen, and D.L. Harnon. J. Anum Feed. Sci. , 295 (2004).
An NMR-based metabolomic approach to assess metabolism in splanchnic tissues of steers
31.  J. C. H. Larsen, B. S. Rasmussen, R. G. Hazell, and T. Skrydstrup. Chem. Comm. , 202 (2004).
Preparation of a novel diphosphine-palladium macrocyclic complex possessing a molecular recognition site. Oxidative addition studies
30.  L. E. Hanford LE, J. J. Enghild, Z. Valnickova, S. V. Petersen, L. M. Schaefer, T. M. Schaefer, T. A. Reinhart TA, and T. D. Oury. J. Biol. Chem. 279, 50019 (2004).
Purification and characterization of mouse soluble receptor for advanced glycation end products (sRAGE)
29.  J. Dittmer and G. Bodenhausen. ChemPhysChem 5, 1750 (2004).
Multiple refocusing in NMR: compensation of pulse imperfections by scalar couplings.
28.  J. Dittmer and G. Bodenhausen. J. Am. Chem. Soc. 126, 1314 (2004).
Evidence for slow motion in proteins by multiple refocusing of heteronuclear nitrogen/proton multiple quantum coherences in NMR.
27.  H. Karring, S. G. Mathu, J. van Duin, B. F. Clark, B. Kraal, and C. B. Knudsen . 279, 1878 (2004).
Qbeta-phage resistance by deletion of the coiled-coil motif in elongation factor Ts
26.  H. Karring, S. G. Mathu, J. van Duin, B. F. Clark, B. Kraal, and C. B. Knudsen . J. Biol. Chem. 279, 1878 (2004).
Qbeta-phage resistance by deletion of the coiled-coil motif in elongation factor Ts
25.  H. Karring, I. B. Th?gersen, G. K. Klintworth Gand J. J. Enghild, and T. M?ller-Pedersen . Mol Cell Proteomics. 3(7), 660 (2004).
Proteomic analysis of the soluble fraction from human corneal fibroblasts with reference to ocular transparency
24.  R. B. Andersen, H. Karring, T. M?ller-Pedersen, Z. Valnickova, I. B. Th?gersen, C. Hedegaard, T. Kristensen, G. K. Klintworth, and J. J. Enghild . Biochemistry 43 (51), 16374 (2004).
Purification and structural characterization of Transforming Growth Factor Beta Induced Protein (TGFBIp) from porcine and human corneas
23.  D. E. Otzen and M. Oliveberg. Protein Sci. 13, 1417 (2004).
Transient formation of nanocrystalline structures during fibrillation of an Alzheimer-like peptide
22.  D. E. Otzen, S. Burlacu, M. Akke, and M. Oliveberg. Biochemistry 43, 12964 (2004).
Transient aggregation and stable dimerization induced by introducing an Alzheimer sequence into a water-soluble protein
21.  J. S. Pedersen, G. Christiansen, and D. E. Otzen . J. Mol. Biol. 341, 575 (2004).
Modulation of S6 fibrillation by unfolding rates and gatekeeper residues
20.  P. H. Justesen, T. Kristensen, T. Ebdrup, and D. E. Otzen. J. Coll. Int. Sci 279, 399 (2004).
Investigating phospholipase action on vesicles and supported planar bilayers using a quartz crystal microbalance
19.  P. Sehgal, H. Doe, M. Sharma, and D. E. Otzen. Colloid Polymer Sci 282, 677 (2004).
Interaction between Phospholipid vesicles and Long Chain Zwitterionic Surfactant
18.  J. E. Mogensen, H. Ibsen, J. Lund, and D. E. Otzen. Biochemistry 43, 3357 (2004).
Elimination of an off-pathway folding intermediate by a single point mutation
17.  D. E. Otzen and M. Oliveberg. Protein Sci. 13, 3253 (2004).
Correspondence between anomalous m- and DeltaCp-values in protein folding
16.  J. E. Mogensen, P. Sehgal, and D. E. Otzen. Biochemistry 44, 1719 (2004).
Activation, inhibition and destabilization of Thermomyces lanuginosus lipase by detergents
15.  S. V. Petersen, A. V. Due, Z. Valnickova, T. D. Oury, and J. D. Crapo j. J. Enghild . Biochemistry 43(44), 14275 (2004).
The structure of rabbit extracellular superoxide dismutase differs from the human protein
14.  R. P. Bowler, B. Duda, E. D. Chan, J. J. Enghild, L. B. Ware, M. A. Matthay, and M. W. Duncan . Am J Physiol Lung Cell Mol Physiol 286(6), 1095 (2004).
Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury
13.  D. A. Olsen, S. V. Petersen, T. D. Oury, Z. Valnickova, I. B. Thogersen, T. Kristensen and R. P. Bowler, J. D. Crapo, and J. J. Enghild. J. Biol. Chem. 279(21), 22152 (2004).
The intracellular proteolytic processing of extracellular superoxide dismutase (EC-SOD) is a two-step event
12.  S. V. Petersen, T. D. Oury, L. ?stergaard, Z. Valnickova, J. Wegrzyn, I. B. Thogersen and C. Jacobsen, R. P. Bowler C. L. Fattman, J. D. Crapo, and J. J. Enghild. J. Biol. Chem. 279(14), 13705 (2004).
Extracellular superoxide dismutase (EC-SOD) binds to type i collagen and protects against oxidative fragmentation
11.  M. Kashiwagi, J. J. Enghild, C. Gendron, C. Hughes, B. Caterson, Y. Itoh, and H. Nagase. J. Biol. Chem. 279(11), 10109 (2004).
Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing
10.  H. Vorum, M. ?stergaard, P. Hensechke, J. J. Enghild, M. Riazati, and G. E. Rice. Proteomics 4(3), 861 (2004).
Proteomic analysis of hyperoxia-induced responses in the human choriocarcinoma cell line JEG-3
9.  J. L. Fowlkes, D. M. Serra, R. C. Bunn, K. M. Thrailkill, J. J. Enghild, and H. Nagase. Endocrinology 145(2), 620 (2004).
Regulation of insulin-like growth factor (IGF)-I action by matrix metalloproteinase-3 involves selective disruption of IGF-I/IGF-binding protein-3 complexes
8.  R. J. Enem?rke, J. Larsen, T. Skrydstrup, and K. Daasbjerg. Organometallics 23, 1866 (2004).
Investigation of the Electrochemical Reduction of Cp2TiCl2
7.  R. J. Enem?rke, J. Larsen, T. Skrydstrup, and K. Daasbjerg. J. Am. Chem. Soc. 126, 7853 (2004).
Revelation of the Nature of the Reducing Species in Titanocene Halide Promoted Reductions
6.  S. A. Johannesen, S. Albu, R. G. Hazell, and T. Skrydstrup. Chem. Commun. , 1962 (2004).
Radical addition of nitrones to acrylates mediated by SmI2: asymmetric synthesis of gamma-amino acids employing carbohydrate-based chiral auxiliaries
5.  M. F. Jacobsen, L. Ionita, and T. Skrydstrup. J. Org. Chem. 69, 4792 (2004).
Highly Stereoselective Mannich-Type Reactions of Chiral N-Acylhydrazones
4.  P. Blakskj?r, A. Gavrila, L. Andersen, and T. Skrydstrup. Tetrahedron Lett. 45, 9091 (2004).
An improved protocol for the SmI2-promoted C-alkylation of peptides: degradation and functionalization of serine residues in linear and cyclic peptides
3.  A. Morello, O. N. Bakharev, H. B. Brom, R. Sessoli, and L. J. de Jongh. Phys. Rev. Lett. 93, 197202 (2004).
Nuclear spin dynamics in the quantum regime of a single-molecule magnet
2.  O. N. Bakharev, I. M. Abu-Shiekah, H. B. Brom, A. A. Nugroho, I. P. McCulloch, and J. Zaanen. Phys. Rev. Lett. 93, 037002 (2004).
NMR evidence for a two-step phase separation in Nd1.85Ce0.15CuO4-d
1.  W. Russell Bowman, Anthony J. Fletcher, Peter J. Lovell, and Jan M. Pedersen. Synlett , 1905 (2004).
Synthesis of indoles using cyclization of imidoyl radicals

Publications - Theses

inSPIN Theses

 
2010
141.  Mads Sloth Vinding. Progress Report. Supervisor: Niels Chr. Nielsen and Sune Jespersen (2010).
Improved Volume Selective Magnetic Resonance Imaging by Optimal Control
140.  Kresten Hagen. Masters Thesis. Supervisor: Niels Chr. Nielsen (2010).
Solid-State NMR on Membrane Proteins
139.  Jerzy Dorosz. Ph.D. Thesis. Supervisor: Niels Chr. Nielsen and Raz Jelinek (2010).
Biophysical characterization of peptide interactions with biomimetic membranes
 
2009
138.  A.B. Nielsen. Part A Progress Report . Supervisor: Niels Chr. Nielsen (2009).
Dipolar recoupling experiments for Biological Solid-State NMR developed using Optimal Control and Analytical Methods.
137.  T. Poulsen. B. Sc. Thesis. Supervisor: T. Skrydstrup (2009).
Asymmetrisk syntese of a-methylserin via Schölkopfs dihydropyrazin-analog.
136.  K. Berglund. B. Sc. Thesis. Supervisor: T. Skrydstrup (2009).
A Study in the Synthesis of a Silicon-Containing Heterocycle.
135.  Christian Gylstorff. B.Sc. Thesis. Supervisor: D. Otzen (2009).
Kinetic stability of T. lanuginosus lipase.
134.  T. Bjerring. B.Sc. Thesis. Supervisor: D. Otzen (2009).
Interactions between lipase and bile salts.
133.  M. Stenvang. B.Sc. Thesis. Supervisor: D. otzen (2009).
Effect of nanoparticles on protein aggregation.
132.  S. Vestergaard. B.Sc. Thesis. Supervisor: D. Otzen and K. Gothelf (2009).
Tailoring aggregation by DNA origami.
131.  Antonello Calcutta. Progress Report. Supervisor: Niels Chr. Nielsen and Anders Malmendal (2009).
Studies of membrane protein folding space by multivariate NMR spectroscopy: the KcsA ion channel
130.  Katrine Mikkelsen. M.Sc. Thesis. Supervisor: Niels Chr. Nielsen and Troels Skrydstrup (2009).
Synthesis of Fibril-binding Organic Compounds and NMR-Studies of their Interactions wiht beta-Amyloid Fibrils
129.  Christoffer Laustsen. M.Sc. Thesis. Supervisor: Niels Chr. Nielsen and M. Petersen (2009).
New and advanced sequences for 23Na NMR imaging, implemented on a 7 T system
128.  Marie Østergaard Pedersen. Ph.D. Thesis. Supervisor: Niels Chr. Nielsen (2009).
Solution and Solid-State NMR of Insoluble Proteins. Amyloid-b in Alzheimer's disease and the Antenna Protein CsmA
127.  Berit Paaske Jensen. Masters Thesis. Supervisor: Thomas Vosegaard (2009).
Static and Dynamic Disorder of Antimicrobial Peptides in Lipid Membranes
 
2008
126.  Marie Østergaard Pedersen. Part A Report. Supervisor: Niels Chr. Nielsen and Jens Dittmer (2008).
NMR structure of a small antenna protein, CsmA, from Chloribium Tepidum initial studies of amyloid-b fibril forming polypeptide involved in Alzheimer's disease
125.  Anna Sigrid Pi Svane. Part A Report. Supervisor: Niels Chr. Nielsen, Anders Malmendal, and Jens Dittmer (2008).
Studies of amyloid fibril formation and peptide-membrane interactions using liquid-state NMR spectroscopy. Glucagon and the HIV-related Tat protein
124.  Kresten Bertelsen. Part A Report. Supervisor: Niels Chr. Nielsen and Thomas Vosegaard (2008).
New methods for studying peptides in lipid bilayers with solid-state NMR spectroscopy
123.  Jerzy Dorosz. Part A Report. Supervisor: Niels Chr. Nielsen and Raz Jelinek (2008).
Molecular mechanism of amyloid and antimicrobial peptide interaction with lipid membranes investigated using diverse biophysical methods
122.  Christoffer Laustsen. Project report. Supervisor: Niels Chr. Nielsen (2008).
Magnetically alligned bicelles
121.  Mads Sloth Vinding. Masters Thesis. Supervisor: Niels Chr. Nielsen (2008).
Optimal control MRI of the chronic stress induced neuroplasticity of the human Hippocampus - a feasibility study
120.  C.B. Cristensen. Ph.D. Thesis. Supervisor: D. Otzen (2008).
Glucagon fibrillation — kinetics and structural polymorphism.
119.  M. Mantel. M.Sc. Thesis. Supervisor: T. Skrydstrup (2008).
Synthesis of the Fibril Binding Compound FSB and Development of an Atom-Efficient Ene-yne Coupling
118.  L. Thim. M.Sc. Thesis. Supervisor: T. Skrydstrup (2008).
Cyclisation of N-Acyl Oxazolidinones Promoted by Samarium Diiodide and Chiral Glucosamine-Based Ligands for Asymmetric Palladium Catalysed Allylic Alkylations
117.  K. Dooleweerdt. M.Sc. Thesis. Supervisor: T. Skrydstrup (2008).
Ynamides – From Their Synthesis Towards Their Applications in Indole Synthesis
116.  J. Grouleff. B. Sc. Thesis. Supervisor: T. Skrydstrup (2008).
An Investigation of Heteroaromatic Tosylates as Electrophiles in the Heck Reaction
115.  D.F. Jensen. B.Sc. Thesis. Supervisor: T. Skrydstrup (2008).
Oxidative Degradation of Collagen Model Peptides
114.  J. Sørensen. M.Sc. Thesis. Supervisor: B. Schiøtt (2008).
Computational Studies of Fibril-forming Proteins
113.  A.U. Christensen. B.Sc. Thesis. Supervisor: B. Schiøtt (2008).
The flip-flop mechanism of the hERa LBD
112.  S.R. Villadsen. B.Sc. Thesis. Supervisor: B. Schiøtt (2008).
Molekylær modellering af paroxetins binding I den humane serotonin transporter
111.  L.V. Jespersen. B.Sc. Thesis. Supervisor: B. Schiøtt (2008).
Computational Studies of Transthyretin – Investigating the Fibril-forming Propensity
110.  L. Celik. Ph.D. Thesis. Supervisor: B. Schiøtt (2008).
Protein, Structure Function and Dynamics Molecular mechanical methods applied to the estrogen receptor a and the serotonin and leucine transporters
109.  J.C.B. Madsen. B.Sc. Thesis. Supervisor: S. Birkelund and T. Kristensen (2008).
The Role of Tryptophan in Chlamydial Infections
108.  L.M. Rydtoft. M.Sc. Thseis. Supervisor: N. C. Nielsen and P. Vestergaard-Poulsen (2008).
Ultra-high-field MRI studies of an Alzheimer’s Disease mouse model.
107.  L. L. Toft. Bachelor thesis. Supervisor: Thomas Vosegaard (2008).
Udvikling af enkeltkrystal add-on
106.  B. Paaske. Project report. Supervisor: Thomas Vosegaard (2008).
COSMOS - complete suppression of mosaic spread
 
2007
105.  Marie Louise Riber-Hansen. Bachelor. Supervisor: Anders Malmendal and Niels Chr. Nielsen (2007).
Collagen degradation measured by NMR spectroscopy
104.  Ronnie Overgaard Pedersen. Bachelor. Supervisor: Niels Chr. Nielsen and Morten Bjerring (2007).
Solid-state NMR analysis of a small fibrillating peptide
103.  Cindie T. Kehlet. Ph.D Thesis. Supervisor: Niels Chr. Nielsen (2007).
Design of NMR experiments for biological applications using optimal control theory
102.  Jarl Underhaug. Ph.D Thesis. Supervisor: Niels Chr. Nielsen (2007).
A structural basis for the understanding of the mechanisms of corneal dystrophies, and other fibrillognic or membrane-associating systems using liquid-state NMR
101.  Klaus T. Nielsen. Masters Thesis. Supervisor: Niels Chr. Nielsen (2007).
Characterization of calcium phosphate nanoclusters and Pd-based artificial enzymes by 31P solid-state NMR spectroscopy
100.  S.R. Midtgaard. B.Sc. Report. Supervisor: Niels Chr. Nielsen and Jens Dittmer (2007).
Studier af tidlige stadier af glucagon fibrillering. Syntese og væske fase NMR analyse af et glucagon decapeptid
99.  K.T. Nielsen. M.Sc. Thesis. Supervisor: Niels Chr. Nielsen (2007).
Characterization of calcium phosphate nanoclusters and Pd-based artificial enzymes by 31P solid-state NMR spectroscopy
98.  S. Nielsen. M.Sc. Thesis. Supervisor: B. Schiøtt and M. Bols (2007).
Studie af bindingen mellem aryl-glykosider og a-cyklodextrin cyanohydrin
97.  M. Laursen. B.Sc. Thesis. Supervisor: B. Schiøtt (2007).
Binding of 1-Azafagomine in b-glucosidase
96.  K.L. Jensen. B.Sc. Thesis. Supervisor: T. Skrydstrup (2007).
En undersøgelse af et ikke-aktiveret fosfat som elektrofil i Sonogashira reaktionen og Suzuki- Miyaura katalyserede vinyleringsreaktioner
95.  J.L.H. Madsen. B.Sc. Thesis. Supervisor: T. Skrydstrup (2007).
Syntese af ketomethylen peptid isosterer ved SmI2 medieret acyl-lignende radikale addition
94.  J.B. Faber. B.Sc. Thesis. Supervisor: T. Skrydstrup (2007).
Siliciumdioler som peptidanaloger–syntese af umiddelbare precursors
93.  S. Kramer. B.Sc. Thesis. Supervisor: T. Skrydstrup (2007).
SmI2-promoverede koblinger af N-acylhydrazoner med n-butylakrylat og t-butyl akrylamid
92.  A.Ø. Nielsen. Bachelor B.Sc. Thesis. Supervisor: T. Skrydstrup (2007).
Synthesis and Investigation of a Monosaccharide-based Aminophophine Ligand in Asymmetric Allylic Alkylation
91.  R. Taaning. M.Sc. Thesis. Supervisor: T. Skrydstrup (2007).
One Step Ahead in the Race Against Resistant Bacteria
90.  T. Mittag. M.Sc. Thesis. Supervisor: T. Skrydstrup (2007).
Development of a New C-Peptide Ligation Methodology: Application to the Fibrillating Peptide NFGAIL
89.  L. Nielsen. M.Sc. Thesis. Supervisor: T. Skrydstrup (2007).
Synthesis of Silanediol Peptide Mimics
88.  M.L. Olesen. M.Sc. Thesis. Supervisor: T. Skrydstrup (2007).
New Synthetic Methodology to Oligochitosans
87.  L.N. Feldborg. M.Sc. Thesis. Supervisor: T. Skrydstrup (2007).
Reductive Enolisation of a-Thioglycolates
86.  A.L. Hansen. Ph.D. Thesis. Supervisor: T. Skrydstrup (2007).
Pd(0) and Ni(0) Catalyzed Transformations–Expanding the Scope of Substrates and Electrophiles
85.  S.A. Johannesen. Ph.D. Thesis. Supervisor: T. Skrydstrup (2007).
Synthesis and as Ligands in Metal Ion Complexes
84.  S.G. Hansen. Ph.D. Thesis. Supervisor: T. Skrydstrup (2007).
Functionalized Thioglucosaminides
83.  C.M. Jensen. . Supervisor: T. Skrydstrup (2007).
Uncovering the Potential of SmI2 in the Formation of a-substitituted g-Keto Esters and Amide.
82.  R.V. Basaiawmoit. Ph.D. Thesis. Supervisor: D. Otzen (2007).
Molecular Mechanisms of Corneal Dystrophies.
81.  D.M.S. Lundvig. Ph.D. Thesis. Supervisor: D. Otzen (2007).
Investigation of the normal function of the brain protein p25a and its relation to demyelinating disorders
80. M. A. Lie. Ph.D. Thesis. Supervisor: B. Schiøtt (2007).
Molecular Modeling of Biochemical Binding and Mechanisms; Exemplified from Enzyme, Protein and Organocatalysis.
79.  P.L. Jensen. M.Sc. Thesis. Supervisor: D. Otzen (2007).
Detection and characterization of amyloid in mycolata species
78.  A. Yde. M.Sc. Thesis. Supervisor: D. Otzen (2007).
Degradation of bacterial amyloid.
77.  L.H. Thomsen. m.Sc. Thesis. Supervisor: D. Otzen (2007).
Acylation of the antimicrobial peptide Novicidin
76.  L. Kjær. M.Sc. Thesis. Supervisor: D. Otzen (2007).
A biophysical study of the interaction of a-synuclein with phospholipid membranes.
75.  J.H. Hansen. M.Sc. Thesis. Supervisor: D. Otzen (2007).
Limited proteolysis as a tool to probe protein conformation in surfactants.
74.  M. Thomsen. M.Sc. Thesis. Supervisor: D. Otzen (2007).
A biophysical investigation of a conformational disease: “Antithrombin III Aalborg.
73.  A.D. Knudsen. M.Sc. Thesis. Supervisor: D. Otzen (2007).
Expression proteomic analysis of cell-lines expressing proteins implicated in Parkinson’s Disease.
72.  K. Sanggaard. Ph.D. Thesis. Supervisor: J. Enghild and T. Kristensen (2007).
The extracellular matrix. Structure, function and interactions of bikunin proteins and TSG-6.
71.  K. Lorentzen. M.Sc. Thesis. Supervisor: J. Enghild (2007).
The extracellular matrix, Structure, Function and Interactions of TSG-6 and Bikunin Protein Family
70.  A. Møller. M. Sc. Thesis. Supervisor: J. Enghild (2007).
Trans fatty acids, Effects of elaidic acid on mRNA and protein expression in HepG2 cells.
69.  L. Hansen. Bachelor Thesis. Supervisor: J. Enghild (2007).
Bikunin Proteins The Purification and Characterisation of Hen Bikunin Proteins.
68.  A.D. Lande. Bachelor Thesis. Supervisor: J. Enghild (2007).
Protein Interactions Between TGFBIp and Corneal or Plasma Proteins.
67.  L.R. Thomsen. Bachelor thesis. Supervisor: J. Enghild (2007).
Comparison of human and bovine ECSOD disulfide bridge pattern.
66.  M.L. Jensen. Bachelor thesis. Supervisor: J. Enghild and Tobias Wang (2007).
Fordøjelsessystemet i kongepython (Python regius) med vægt på proteaser.
65.  A.N. Larsen. Bachelot thesis. Supervisor: J. Enghild and T. Wang (2007).
Digestive system of Python regius with main focus on proteases
64.  D. Christensen. Bachelor thesis. Supervisor: B. Schiøtt and L. Thøgersen (2007).
Alamethicins kanalegenskaber.
63.  S.N. Thomsen. Bachelot thesis. Supervisor: T. Kristensen and T. Wang (2007).
Discovery and Cloning of the Reptilian Na+/H+ Transporter (Isoform 1)
62.  R.W. Rasmussen. Bachelor thesis. Supervisor: T. Kristensen and D.D. Bang (2007).
Cytolethal Distending Toxin B Gene of Campylobacter upsaliensis Isolated from Human and Dog.
61.  M. Kragballe. Bachelor thesis. Supervisor: T. Kristensen and O. Wiborg (2007).
Functional Regulation of the Serotonin Transporter by Cannabinoid Receptor Interacting Protein, CRIP1a
60.  B. Kocaman. M.Sc. Thesis. Supervisor: T. Kristensen (2007).
Cloning and Characterization of two Cysteine Protease cDNAs in the Carnivorous Venus flytrap Plant, and Developing HEK293 Cell Lines Stably Expressing Venus flytrap Cysteine Proteases
59.  K.L. Christensen. M.Sc. Thesis. Supervisor: T. Skrydstrup (2007).
Application of SmI2 for the Synthesis of Peptide Mimics.
 
2006
58.  J. Underhaug. Progress Report. Supervisor: Niels Chr. Nielsen (2006).
Structure of Membrane Peptides and Side-Chain Dynamics of Proteins by Liquid-State NMR
57.  M. K. Sørensen. Bachelor Report. Supervisor: Thomas Vosegaard and Niels Chr. Nielsen (2006).
Solid phase peptide synthesis and solid-state NMR characterization of a fibrillating prion peptide
56.  K. Jahn. Bachelor Report. Supervisor: Jens Dittmer and Niels Chr. Nielsen (2006).
Væskefase NMR undersøgelser af glucagon
55.  Søren Roi Midtgaard. Bachelor. Supervisor: Jens Dittmer and Niels Chr. Nielsen (2006).
54.  P. Würtz. Masters Thesis. Supervisor: Niels Chr. Nielsen (2006).
Pulse sequence design for biomolecular NMR spectrosc
53.  Julie Søgaard Nielsen. Project Report. Supervisor: Morten Bjerring and Niels Chr. Nielsen (2006).
Solid-state NMR study of photovoltaic polymers stabilized by hydrogen bonded networks
52.  Anders Bodholt Nielsen. Bachelor Thesis. Supervisor: Niels Chr. Nielsen (2006).
Symmetribaserede rekoblingssekvenser til biologisk faststof NMR udviklet med optimal control teori
51.  Lasse Arnt Straasøe. Bachelor Thesis. Supervisor: Niels Chr. Nielsen (2006).
Approksimativ formulering af exact effective Hamiltonian teori som alternative til average Hamiltonian teori ved udvikling af NMR eksperimenter
50.  A.-M. Hansen. M.Sc. thesis. Supervisor: T. Skrydstrup (2006).
Development of a New Carbon-Carbon Bond Forming Reaction Promoted by Samarium Diiodide
49.  S. S. Hansen. M.Sc. thesis. Supervisor: T. Skrydstrup (2006).
Studies Directed to Understanding the Conformation of Chitosan
48.  R. Birkler. M.Sc. thesis. Supervisor: T. Skrydstrup (2006).
Synthesis of Ligands for Improved Drug Delivery Molecules in Gene Therapy
47.  J. Karaffa. M.Sc. thesis. Supervisor: T. Skrydstrup (2006).
Uncovering the Potential of SmI2 in the Formation of alpha-substitituted gamma-Keto Esters and Amides
46.  R. Birkler. B.Sc. thesis. Supervisor: T. Skrydstrup (2006).
Synthesis of Peptides for Drug Delivery
45.  M.L. Olesen. B.Sc. thesis. Supervisor: T. Skrydstrup (2006).
Syntese af chitosan oligosaccharider
44.  T. Gøgsig. B.Sc. thesis. Supervisor: T. Skrydstrup (2006).
En undersøgelse af 1,2-Pd migration i Heck koblingen og Vinyl phosphater i metalkatalyserede krydskoblinger
43.  C.U. Hjørringgaard. B.Sc. Thesis. Supervisor: T. Skrydstrup (2006).
Syntese af potentielle beta-amyloid-bindende molekyler
42.  J.S. Petersen. B.Sc. Thesis. Supervisor: T. Skrydstrup (2006).
Syntese af EF-Tu inhibitorer
41.  L. Celik. Part A report of Ph.D.. Supervisor: B. Schiøtt (2006).
Molecular Modeling of Selected Poteins
40.  J.D.D. Lund. M.Sc. Thesis. Supervisor: B. Schiøtt (2006).
Molecular Modeling of EF-Tu.
39.  H. Koldsø. B.Sc. Thesis. Supervisor: B. Schiøtt (2006).
Structural Insight into Citalopram Binding in the human Serotonin Transporter. A Molecular Modeling Study.
38.  M. Musgaard. B.Sc. Thesis. Supervisor: B. Schiøtt (2006).
Insights into Binding of Imipramine and Analogues to the Human Serotonin Transporter - An Induced Fit Docking Study
37.  L. Ramsgaard. M.Sc. Thesis. Supervisor: T. Kristensen (2006).
Characterization of the proteolytic cleavage of human extracellular superoxide dismutase and intra- and extracellular presence of active- and inactive extracellular superoxide dismutase.
36.  E. T. Poulsen. B.Sc. Thesis. Supervisor: J. J. Enghild (2006).
Cleavage of Prolyl bonds in collagen peptides analogues by reactive oxygen species.
35.  J.S. Pedersen. Ph.D. Thesis. Supervisor: D. Otzen (2006).
In vitro studies of amyloid-like protein fibrils using glucagons as model system
34.  S.K. Knudsen. M.Sc. Thesis. Supervisor: D. Otzen (2006).
Effects of glycosylation on biophysical and flocculation of the extra cellular domain of Ag43
33.  M.M. Nielsen. M.Sc. Thesis. Supervisor: D. Otzen (2006).
Stability of b-sheet proteins against unfolding in detergent.
32.  M.S. Dueholm. M.Sc. Thesis. Supervisor: D. Otzen (2006).
Purification and characterization of bacterial amyloid fibrils.
31.  L.K. Engelbrecht. M.Sc. Thesis. Supervisor: D. Otzen (2006).
Inhibition of protein aggregation by green tea components.
30.  K. Pedersen. Bachelor Thesis. Supervisor: T. Kristensen (2006).
Alpha-1-adrenoceptors.
 
2005
29.  M. Bjerring. Ph.D. Thesis. Supervisor: Niels Chr. Nielsen (2005).
Development of Dipolar Recoupling Methods and Applications in Biological Solid-State NMR
28.  C. Kehlet. Progress Report. Supervisor: Niels Chr. Nielsen (2005).
Optimal Control Theory for the Design of NMR Experiments for Biological Applicatoins
27.  A.C. Sivertsen. Ph.D Thesis. Supervisor: Niels Chr. Nielsen and Jack Schaefer (2005).
Aspects for Biological Solid-State NMR: From Protein Expression to Design of New Pulse Elements
26.  A.S.P. Svane. Bachelor Report. Supervisor: Niels Chr. Nielsen, Thomas Vosegaard (2005).
A liquid-state NMR study of the fibrillation of a conjugated bis peptide from prion octarepeat
25.  C.C. Yde. Masters Thesis. Supervisor: Niels Chr. Nielsen, Thomas Vosegaard, and Anders Malmendal (2005).
Characterization of pardaxin in biological membrane-mimicking environments by CD, ATR-FTIR, solution and solid-state NMR spectroscopy
24.  K. Nielsen. Project Report. Supervisor: Niels Chr. Nielsen (2005).
Calcium phosphate nanoclusters
23.  L. Ottesen. Masters Thesis. Supervisor: T. Skrydstrup and R. Olsson (2005).
Cross-coupling reactions with imidoyl chlorides
22.  R. Taaning. Bachelor Report. Supervisor: T. Skrydstrup (2005).
Carbon-carbon bond formation via acyl-like radical additions.
21.  L. Thim. Bachelor Report. Supervisor: T. Skrydstrup (2005).
Synthesis of mannose modified chitosans.
20.  K. Christensen. Bachelor Report. Supervisor: T. Skrydstrup (2005).
New methods for the introduction of sidechains onto small peptides.
19.  J.E. Mogensen. Ph.D. thesis. Supervisor: D. Otzen (2005).
Studies on protein-detergent interactions using the autotransporter AIDA from E. coli and the lipase from T. lanuginosus as model proteins.
18.  L. Giehm. M.Sc. thesis. Supervisor: D. Otzen (2005).
Biophysical analysis of a concatemer of the Alzheimer beta peptide.
17.  B. Vad. M. Sc. thesis. Supervisor: D. Otzen (2005).
Investigating structural features of the transmembrane proteisn DsbB and AIDA-I by the use of crystallography and Atomic Force Microscopy.
16.  S. Mølgaard. M.Sc. thesis. Supervisor: D. Otzen (2005).
Association of transmembrane protein fragments.
15.  M. Davidsen. M.Sc. thesis. Supervisor: D. Otzen (2005).
Influence of lipids on glucagon fibrillation.
14.  C. Christensen. M.Sc. thesis. Supervisor: D. Otzen (2005).
Dendrimers and protein aggregation.
13.  K. Andersen. M.Sc. thesis. Supervisor: D. Otzen (2005).
Mechanism of unfolding of OmpA in lipid bilayers.
12.  T. Christensen. M.Sc. thesis. Supervisor: J. Enghild (2005).
Purification of human thrombin activatable fibrinolysis inhibitor.
11.  A. Due. M.Sc. thesis. Supervisor: J. Enghild (2005).
Structural and functional aspects of human and rabbit extracellular superoxide dismutase.
10.  L. Grubach. bachelor thesis. Supervisor: J. Enghild (2005).
Characterization of bovine EC-SOD.
9.  A. Møller. bachelor thesis. Supervisor: J. Enghild (2005).
Extracellular superoxide dismutase types in blood and urine.
8.  T. Østergaard. M.Sc. thesis. Supervisor: J. Enghild (2005).
Studies on the Human and Porcine Cornea -Transparency and Proteomics.
7.  J. Lund. B. Sc. thesis. Supervisor: B. Schiøtt (2005).
The Estrogen Receptor
6.  J. Sørensen. B.Sc. thesis. Supervisor: B. Schiøtt (2005).
Theoretical Study of short strong hydrogen bonds.
5.  S. Christensen. Bachelor thesis. Supervisor: T. Kristensen (2005).
Sortilin, Karakterisering af en ny Receptor.
 
2004
4.  L. Odgaard Jakobsen. Ph.D. Thesis. Supervisor: Mikael Esmann and Niels Chr. Nielsen (2004).
Structural studies of cation and nucleotide binding sites in the NA,K-ATPase
3. K. S. Hagen. Bachelor Report. Supervisor: Niels Chr. Nielsen (2004).
Faststof NMR p? orienterede membranproteiner
2.  Peter Würtz. . Supervisor: Niels Chr. Nielsen (2004).
Measuring residual dipolar couplings of the alpha carbon site: A new set of spin-state selective HCACO experiments
1.  P. Dahl. Bachelor Report. Supervisor: Niels Chr. Nielsen (2004).
Cloning of Aquaporin-1


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Page last updated on June 17, 2010 by Thomas Vosegaard